Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Dec;193(3):807-11.
doi: 10.1148/radiology.193.3.7972829.

Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT

S L Aquino  1 , G Gamsu, J V Fahy, S Claster, S H Embury, W C Mentzer, E P Vichinsky
Affiliations

Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT

S L Aquino et al. Radiology. 1994 Dec.

Abstract

Purpose: To characterize the non-acute abnormalities seen at computed tomography (CT) in patients with sickle cell (SC) disease and a prior history of acute chest syndrome (ACS)-pneumonia.

Materials and methods: Twenty-nine patients with SC disease who had experienced one to more than 10 (median, six) previous episodes of ACS-pneumonia were prospectively studied with thin-section CT of the thorax. Scans were graded for interstitial disease and assigned a disease index ranging from 0 to 3. Twenty-four patients underwent pulmonary function tests (PFTs) and measurement of their blood gasses.

Results: Twelve of the 29 patients (41%) had significant interstitial disease that was multifocal. A correlation was found between the disease index and number of episodes of ACS-pneumonia (P = .02) but not between the disease index and PFT results.

Conclusion: Thin-section CT demonstrates significant multifocal interstitial lung abnormalities in 41% of selected patients with SC disease. The pattern is most consistent with scarring from episodes of infarction or infection.

PubMed Disclaimer

Publication types

LinkOut - more resources