Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Jul;13(13-14):1453-8.
doi: 10.1002/sim.4780131321.

Stopping when the experimental regimen does not appear to help

S Wieand  1 , G Schroeder, J R O'Fallon
Affiliations
Comparative Study

Stopping when the experimental regimen does not appear to help

S Wieand et al. Stat Med. 1994 Jul.

Abstract

We discuss a procedure that offers the possibility of reducing the number of patients assigned to experimental regimens which are no more effective than a standard regimen. The procedure is useful in advanced cancer trials in which the length of the accrual period might be more than twice the median survival time for the standard regimen. The procedure is intuitively appealing and offers a 50 per cent chance of stopping accrual to ineffective therapies, yet is associated with a loss of power of less than 0.02.

PubMed Disclaimer

Publication types

MeSH terms