Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov 25;266(5189):1376-80.
doi: 10.1126/science.7973727.

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

M L Smith  1 , I T Chen, Q Zhan, I Bae, C Y Chen, T M Gilmer, M B Kastan, P M O'Connor, A J Fornace Jr
Affiliations

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

M L Smith et al. Science. .

Abstract

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

PubMed Disclaimer

Comment in

Publication types