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. 1994 Jul;12(9):773-5.
doi: 10.1016/0264-410x(94)90284-4.

Increased encapsulation and virulence of Francisella tularensis live vaccine strain (LVS) by subculturing on synthetic medium

J W Cherwonogrodzky  1 , M H Knodel, M R Spence
Affiliations

Increased encapsulation and virulence of Francisella tularensis live vaccine strain (LVS) by subculturing on synthetic medium

J W Cherwonogrodzky et al. Vaccine. 1994 Jul.

Abstract

Francisella tularensis live vaccine strain (LVS), taken directly from lyophilized vials, did not appear to have a capsule and had low virulence for Balb/c mice. When this strain was subcultured on Chamberlain's synthetic medium (pH 6.5), it became extensively capsulated (1-5 micron in diameter) and its virulence for Balb/c mice increased about 1000-fold. We conclude that the virulence of the attenuated vaccine strain, F. tularensis LVS, may still be influenced by growth conditions.

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