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. 1976 Oct;67(5):733-6.

Adjuvant and antitumor activities of Nocardia cell-wall skeletons

I Azuma, T Taniyama, M Yamawaki, K Sugimura, Y Yamamura
  • PMID: 797626

Adjuvant and antitumor activities of Nocardia cell-wall skeletons

I Azuma et al. Gan. 1976 Oct.

Abstract

The adjuvant activity of the cell-wall skeletons prepared from eight species (ten strains) of Nocardia was determined by Brunner's method using allogeneic cell-mediated cytotoxicity test. The antitumor activity of the cell-wall skeleton of N. rubra, which showed the most potent adjuvant activity, was examined using EL-4 leukemia and MH-134 hepatoma cells in syngeneic mice. Its results suggest that the cell-wall skeleton of N. rubra is more potent than BCG cell-wall skeleton as the immunotherapeutic agent for cancer immunotherapy in man. The chemical properties of the cell-wall skeleton of N. rubra were also described.

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