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. 1994 Jun:41 Spec No:C60-1.
doi: 10.1007/BF02007767.

Histamine is a powerful stimulator of cyclic AMP formation in chick pineal gland

J Z Nowak  1 , B Sek
Affiliations

Histamine is a powerful stimulator of cyclic AMP formation in chick pineal gland

J Z Nowak et al. Agents Actions. 1994 Jun.

Abstract

Histamine (HA) potently stimulated both basal and forskolin-activated cAMP formation in chick pineal gland. The action of HA was mimicked by 4-methyl-HA, and to some extent by 2-methyl-HA and 2-thiazolylethylamine (2TEA), but not by dimaprit, (R)-alpha-methyl-HA tele-methyl-HA, and several other imidazole-derivatives. The stimulatory actions of all the compounds were antagonized by ranitidine and tiotidine (HA H2-receptor antagonists), and were not affected by mepyramine and thioperamide (HA H1- and H3-receptor blockers, respectively). These data indicate that the chick pineal probably contains H2-like HA receptors, whose stimulation leads to increases in cAMP production.

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