Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov;55(5):870-5.

Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21

E Steichen-Gersdorf  1 , H H Gallion, D Ford, C Girodet, D F Easton, R A DiCioccio, G Evans, M A Ponder, C Pye, S Mazoyer, et al.
Affiliations

Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21

E Steichen-Gersdorf et al. Am J Hum Genet. 1994 Nov.

Abstract

In a study of nine families with "site-specific" ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age < 50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.

PubMed Disclaimer

Comment in

References

    1. Hum Mol Genet. 1993 Nov;2(11):1823-8 - PubMed
    1. Lancet. 1994 Mar 19;343(8899):692-5 - PubMed
    1. Genes Chromosomes Cancer. 1994 May;10(1):71-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed
    1. Am J Med. 1986 Dec;81(6):1073-6 - PubMed

Publication types