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Meta-Analysis
. 1994 Nov;171(5):1328-34.
doi: 10.1016/0002-9378(94)90156-2.

A meta-analysis of randomized trials of prenatal smoking cessation interventions

P Dolan-Mullen  1 , G Ramírez, J Y Groff
Affiliations
Meta-Analysis

A meta-analysis of randomized trials of prenatal smoking cessation interventions

P Dolan-Mullen et al. Am J Obstet Gynecol. 1994 Nov.

Abstract

Objective: Our purpose was to assess the effect of prenatal smoking interventions on rates of smoking cessation and low birth weight.

Study design: We used a meta-analysis model to compare and summarize smoking cessation and low birth weight outcomes with the risk ratio used as a common metric. We located 11 randomized, controlled trials with objective validation of smoking status; four of these studies also measured rates of low birth weight.

Results: Risk ratios for smoking cessation ranged from 0.9 to 7.1. The combined risk ratio for the homogeneous group of 10 studies was 1.50 (95% confidence interval 1.22 to 1.86) after the outlier study with a risk ratio of 7.1 was excluded. This was a 50% increase in smoking cessation. Low birth weight risk ratios of 0.6 for two studies that achieved a 50% increase in cessation suggested that the incidence of low birth weight was decreased.

Conclusion: Prenatal smoking cessation interventions increase rates of smoking cessation during pregnancy, and there is evidence that they reduce the incidence of low birth weight.

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