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. 1994 Jun;24(3):301-3.
doi: 10.1111/j.1445-5994.1994.tb02176.x.

Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model

A E Davis  1 , F Patterson
Affiliations

Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model

A E Davis et al. Aust N Z J Med. 1994 Jun.

Abstract

Background: Epidemiological studies in humans suggest that regular use of non-steroidal anti-inflammatory drugs (NSAIDS) especially aspirin significantly decreases the risk of developing colorectal cancer.

Aims: The purpose of this study was to investigate the effect of aspirin on colonic carcinogenesis using the dimethylhydrazine (DMH) colonic cancer model in rats.

Methods: Groups of animals were given daily doses of aspirin either 0, 5, 30 or 60 mg/kg for 18 weeks. Half of each group also received 18 x 30 mg/kg/wk injections of DMH.

Results: Aspirin at doses of 5, 30 or 60 mg/kg/dy had a progressive effect on the reduction of tumour numbers and the percentage of tumours greater or equal to 5 mm in diameter. Aspirin at doses of 30 and 60 mg/kg/dy significantly reduced tumour incidence.

Conclusion: These findings support the epidemiological studies in humans. The rat DMH model would appear to be suitable for investigating the mechanism of action of aspirin in reducing colonic tumour formation.

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