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Case Reports
. 1994 Nov;37(11):1698-703.
doi: 10.1002/art.1780371120.

Concentration of autoantibodies to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block

M Reichlin  1 , A Brucato, M B Frank, P J Maddison, V R McCubbin, M Wolfson-Reichlin, L A Lee
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Free article
Case Reports

Concentration of autoantibodies to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block

M Reichlin et al. Arthritis Rheum. 1994 Nov.
Free article

Abstract

Objective: To determine the serologic specificity of acid eluates from tissues of a child who died with congenital complete heart block (CCHB).

Methods: Tissues were extracted, acid eluted, and the IgG and antibody titers determined on the eluates by enzyme-linked immunosorbent assay.

Results: Antibodies to native 60-kd and denatured 52-kd Ro/SS-A were found to be enriched only in the heart eluate, and not in the eluates from brain, kidney, and skin.

Conclusion: These findings indicate a major role for anti-native 60-kd Ro/SS-A in the immunopathogenesis of CCHB.

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