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. 1978 Aug 26;2(8087):446-9.
doi: 10.1016/s0140-6736(78)91445-9.

Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease

A W Segal, O T Jones, D Webster, A C Allison

Absence of a newly described cytochrome b from neutrophils of patients with chronic granulomatous disease

A W Segal et al. Lancet. .

Abstract

A unique cytochrome b which becomes incorporated into phagocytic vacuoles has been described in human neutrophils. This cytochrome b appears to be situated in the plasma membrane of these cells, and acts as a component of the microbicidal oxidase system. Absence or gross abnormality of this cytochrome b was demonstrated in all four patients with chronic granulomatous disease who were investigated, and reduced concentrations in two mothers known to be carriers of the disease.

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