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. 1994 Jul;66(1):11-20.
doi: 10.1016/0166-6851(94)90031-0.

An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins

P J Myler  1 , M J Lodes, G Merlin, T de Vos, K D Stuart
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An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins

P J Myler et al. Mol Biochem Parasitol. 1994 Jul.

Abstract

LD1 is a 27.5-kb sequence that occurs in an approx. 2.2-Mb chromosome in all species and strains of Leishmania. In Leishmania infantum MHOM/BL/67/ITMAP263, LD1 is also present as an inverted dimeric repeat in multicopy, 55-kb circular molecules. Sequence analysis of a 7873-nt segment derived from the circular DNA reveals 4 open reading frames (ORFs) with potential protein coding function. One ORF predicts a protein with an ATP/GTP binding site motif. Another ORF predicts a protein with 10-12 potential membrane-spanning domains, suggesting that it encodes an integral membrane protein. This protein also has homology with that predicted by the ESAG10 gene of Trypanosoma brucei.

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