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Review
. 1994 Dec;41(6):1227-43.
doi: 10.1016/s0031-3955(16)38870-8.

Therapeutic drug monitoring in the pediatric intensive care unit

M D Reed  1 , J L Blumer
Affiliations
Review

Therapeutic drug monitoring in the pediatric intensive care unit

M D Reed et al. Pediatr Clin North Am. 1994 Dec.

Abstract

Drugs are administered in the pediatric intensive care unit using either a target-effect or a target-concentration strategy. In the former, drug dose is escalated until the predetermined target-effect is achieved, no further pharmacologic effect is obtained with incremental increases in dose, or toxicity supervenes. When the target-concentration strategy is used, drug therapy is adjusted to achieve serum/plasma drug concentrations within an accepted therapeutic range. This strategy does not recognize interindividual differences in drug responsiveness. Therapeutic drug monitoring in the pediatric intensive care unit is further confounded by the limited data available concerning the effects of the other technologies used on drug disposition and the paucity of information related to therapeutic agents in pediatric patients. Clearly therapeutic drug monitoring in the pediatric intensive care unit is a daunting challenge.

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