[Gene geography of hereditary glucose-6-phosphate dehydrogenase deficiency and pulmonary tuberculosis in Azerbaijan]

Abstract

A comparative study of the detection rate for glucose-6-phosphate dehydrogenase (G-6-PDH) deficiency was carried out among the indigenous population of different regions of Azerbaijan with epidemiologic tuberculosis situation. A screening comprising the Bernstein test (for revealing enzymopathy in the erythroid series cells) and the NS test (for revealing enzyme deficiency in leukocytes) was conducted to find hereditary G-6-PDH deficiency. A comparison of the epidemiologic parameters of the pertinent regions revealed the correlation between the detection rate for G-6-PDH deficiency in the republican regions and the epidemiologic tuberculosis situation. These studies have led to the conclusion that one of the measures to reduce tuberculosis morbidity in the republic is to enhance antiepidemiologic measures in the regions whose residents show a high incidence fo hereditary G-6-PDH deficiency.