[Pharmacological treatment of depression]

Abstract

Major depression is a frequent and incapacitating illness. Recent research has established its natural course, often characterised by chronicity or recurrent episodes, leading to long-term pharmacotherapy. Effective pharmacologic treatments are available for depression, including tricyclic antidepressants, monoamine oxidase-inhibiting agents, and newer medications. Successful pharmacotherapy for depression requires consideration of the profile of the antidepressant drugs, to balance their therapeutic effects and side effects profiles.