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Review
. 1994 Oct;10(10):365-71.
doi: 10.1016/0168-9525(94)90133-3.

Genetic control of host resistance to infection

D Malo  1 , E Skamene
Affiliations
Review

Genetic control of host resistance to infection

D Malo et al. Trends Genet. 1994 Oct.

Abstract

Human resistance to infectious diseases is often regulated by multiple genes that control different aspects of host-parasite interaction. Genetically distinct inbred strains of mice that differ in their susceptibility to specific pathogens are invaluable for dissecting such complex patterns and have allowed the identification of several host-resistance loci that regulate natural and acquired immunity in response to infection. Cloning these genes is the first step in elucidating their roles in host defense.

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