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. 1994 Sep;33(3):261-8.
doi: 10.1016/0168-1702(94)90107-4.

Virus-like particles in MDCK cells persistently infected with Borna disease virus

R W Compans  1 , L R Melsen, J C de la Torre
Affiliations

Virus-like particles in MDCK cells persistently infected with Borna disease virus

R W Compans et al. Virus Res. 1994 Sep.

Abstract

A line of Madin Darby canine kidney (MDCK) cells persistently infected with Borna disease virus was examined by electron microscopy. Thin sections revealed the presence of intracytoplasmic virus-like particles ranging from 50-100 nm in diameter. Nuclei of the infected cells exhibited accumulation of electron-dense granular structures 15-18 nm in diameter. The intracytoplasmic particles were roughly spherical with a limiting membrane, suggesting the presence of a lipid-containing envelope. The internal structure consisted of strand-like material which in some cases was condensed underneath the envelope. The possible relationship of these particles to Borna disease virions is discussed.

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