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. 1994 Oct;60(10):3881-3.
doi: 10.1128/aem.60.10.3881-3883.1994.

Identification of a heroin esterase in Rhodococcus sp. strain H1

G W Cameron  1 , K N Jordan, P J Holt, P B Baker, C R Lowe, N C Bruce
Affiliations

Identification of a heroin esterase in Rhodococcus sp. strain H1

G W Cameron et al. Appl Environ Microbiol. 1994 Oct.

Abstract

A strain of a Rhodococcus sp. (termed H1) capable of utilizing heroin as its sole carbon and energy source was isolated by selective enrichment. An inducible heroin esterase was partially purified and shown to catalyze the hydrolysis of both of the acetylester groups of heroin. The enzyme displays optimum activity at pH 8.5 and appears to be a trimer of identical subunits with an M(r) or 39,000 and a native M(r) of 120,000.

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