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. 1994 Dec;37(12):1798-803.
doi: 10.1002/art.1780371214.

Outcome of polyarteritis nodosa and Churg-Strauss syndrome. An analysis of twenty-five patients

M Abu-Shakra  1 , H Smythe, J Lewtas, E Badley, D Weber, E Keystone
Affiliations

Outcome of polyarteritis nodosa and Churg-Strauss syndrome. An analysis of twenty-five patients

M Abu-Shakra et al. Arthritis Rheum. 1994 Dec.

Abstract

Objective: To compare outcome in patients with polyarteritis nodosa (PAN) and patients with Churg-Strauss syndrome (CSS) followed up at a single center.

Methods: A retrospective data review of 13 patients with PAN and 12 patients with CSS who were followed up at a vasculitis clinic. Outcome measures included a global damage index, disability and pain dimensions of the Health Assessment Questionnaire, and mortality rate.

Results: Compared with patients with CSS, patients with PAN had a significantly higher mean damage index score (5.15 versus 2.42; P = 0.011), a higher disability score (1.09 versus 0.16; P = 0.007), and a higher pain score (1.04 versus 0.01; P = 0.017). Patients with PAN had more relapses (relative risk = 5.07; P < 0.000) and a higher mortality rate (31%) compared with patients with CSS (8%).

Conclusion: PAN and CSS differ in their morbidity and mortality; therefore, they should be considered as distinct clinical entities.

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