Unchanged neurogenic vasoconstrictor response after exercise during angiotensin converting enzyme inhibition with fosinopril

Abstract

In a double-blind, randomized, cross-over, placebo- and rest-period controlled study with two 4-week treatment periods, we examined the effects of angiotensin converting enzyme (ACE) inhibition with fosinopril (20 mg/day) on the postexercise pressor and forearm vasoconstrictor responses to a 60 sec cold pressor test. The results indicate that pressor and vasoconstrictor responses were unaffected by prior exercise, fosinopril, and both interventions combined. Expression of the responses as percent change from baseline levels provided identical results indicating that changes in baseline values did not mask an altered vascular responsiveness. It is concluded that skeletal muscle vascular responsiveness to sympathetic nervous activity is unchanged after exercise or during ACE inhibition with fosinopril.