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. 1978 Sep 2;2(8088):494-6.
doi: 10.1016/s0140-6736(78)92218-3.

Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus

T Hewer, E Rose, P Ghadirian, M Castegnaro, C Malaveille, H Bartsch, N Day

Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus

T Hewer et al. Lancet. .

Abstract

Substances which are commonly sucked or chewed in two areas where the incidence of oesophageal cancer is high, the Transkei and north-east Iran, were tested in bacterial mutagenicity assays. Pyrolysed substances, opium dross in north-east Iran and tobacco pipe residues in the Transkei, displayed mutagenic activity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver microsomes.

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