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Comparative Study
. 1994 Nov 23;1196(1):97-9.
doi: 10.1016/0005-2736(94)90301-8.

Molecular cloning and functional expression of the guinea pig cardiac Na(+)-Ca2+ exchanger

Y Tsuruya  1 , M M Bersohn, Z Li, D A Nicoll, K D Philipson
Affiliations
Comparative Study

Molecular cloning and functional expression of the guinea pig cardiac Na(+)-Ca2+ exchanger

Y Tsuruya et al. Biochim Biophys Acta. .

Abstract

The cDNA of the guinea pig cardiac Na(+)-Ca2+ exchanger was cloned from a lambda ZAP cDNA library. The deduced sequence of the protein corresponds to 970 amino acids and is 98% identical to the canine cardiac exchanger. The leader peptide region shows substantial variation among species. The cloned cDNA can induce Na(+)-Ca2+ exchange activity when in vitro transcribed cRNA is injected into Xenopus laevis oocytes.

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