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. 1994 Aug;3(8):1393-9.
doi: 10.1093/hmg/3.8.1393.

Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene

M Peyrard  1 , I Fransson, Y G Xie, F Y Han, M H Ruttledge, S Swahn, J E Collins, I Dunham, V P Collins, J P Dumanski
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Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene

M Peyrard et al. Hum Mol Genet. 1994 Aug.

Abstract

A 140 kb homozygous deletion from 22q12 in one meningioma directed us towards the cloning and characterization of a new member of the human beta-adaptin gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated in the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene.

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