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. 1994 Jul;46(1 Spec No):88-91.
doi: 10.1111/j.1399-0004.1994.tb04208.x.

Genetic markers in hypercholesterolemic and normocholesterolemic Czech children

R Poledne  1 , J Hubácek, Z Písa, H Pistulková, Z Valenta
Affiliations

Genetic markers in hypercholesterolemic and normocholesterolemic Czech children

R Poledne et al. Clin Genet. 1994 Jul.

Abstract

The genetic background of polygenic hypercholesterolemia was studied in hypercholesterolemic children consuming a diet identical to control individuals with low cholesterol concentrations. Significantly higher frequencies of "disadvantage" alleles, usually combined with a higher LDL cholesterol, were found in hypercholesterolemic individuals when polymorphisms in apolipoprotein E, apolipoprotein B--XbaI and LDL receptor--PvuII were studied.

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