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. 1994 Dec 8;372(6506):519-24.
doi: 10.1038/372519a0.

Long-term synapse loss induced by focal blockade of postsynaptic receptors

R J Balice-Gordon  1 , J W Lichtman
Affiliations

Long-term synapse loss induced by focal blockade of postsynaptic receptors

R J Balice-Gordon et al. Nature. .

Abstract

Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.

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