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Case Reports
. 1994 Aug;20(7):511-2.
doi: 10.1007/BF01711907.

Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia

F Leclerc  1 , Y Riou, A Martinot, L Storme, V Hue, V Flurin, A Deschildre, A Sadik
Affiliations
Case Reports

Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia

F Leclerc et al. Intensive Care Med. 1994 Aug.

Abstract

Objective: To report the first case of ARDS in children treated with nitric oxide (NO) inhalation.

Methods: A 13-months infant presented with BPD and severe hypoxemia related to RSV infection and ARDS. Inhaled NO was delivered in the ventilatory circuit of a continuous flow ventilator (Babylog 8000, Dräger) in a concentration of 20-80 ppm for 7 days. NO and NO2 were continuously monitored (Polyton Draeger). Respiratory mechanics were evaluated by using the method of passive inflation by the ventilator.

Results: NO inhalation improved oxygenation (tcSaO2) and reduced respiratory system resistance without affecting arterial pressure. NO2 level remained below 5 ppm, and methaemoglobin level below 1%. The child survived without neurologic sequela.

Conclusions: Two mechanisms to explain oxygenation improvement can be suggested: selective improvement in perfusion of ventilated regions and bronchodilation.

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