[Use of the modified Warthin-Starry method in pigmented nevi of the skin]

Abstract

Warthin-Starry method is an argyrophilic method, performed at ph 3.2. It is a very efficient method for demonstration of melanin pigment granules in the nevus tissue and in malignant melanoma. We have concluded that it is highly specific for demonstration of melanin pigment granules, and more efficient than the Fontan-Masson method. The Fontan-Mason method reduces other pigments in the cell, apart from melanin. Modified Warthin-Starry method at ph 3.2 in the nevus tissue reduces only melanin pigment granules.