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. 1994 Dec;372(6508):746-54.
doi: 10.1038/372746a0.

Crystal structure of the tyrosine kinase domain of the human insulin receptor

S R Hubbard  1 , L Wei, L Ellis, W A Hendrickson
Affiliations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

S R Hubbard et al. Nature. 1994 Dec.

Abstract

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

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