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. 1994 Oct;60(5):391-4.
doi: 10.1055/s-2006-959516.

Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine

Y Suzuki  1 , T Oyama, A Ishige, T Isono, A Asami, Y Ikeda, M Noguchi, Y Omiya
Affiliations

Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine

Y Suzuki et al. Planta Med. 1994 Oct.

Abstract

We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.

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