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. 1994;138(3-4):391-401.
doi: 10.1007/BF01379143.

Replication of human cytomegalovirus in a rhabdomyosarcoma cell line depends on the state of differentiation of the cells

J Cinatl Jr  1 , J Cinatl, K Radsak, H Rabenau, B Weber, M Novak, R Benda, B Kornhuber, H W Doerr
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Replication of human cytomegalovirus in a rhabdomyosarcoma cell line depends on the state of differentiation of the cells

J Cinatl Jr et al. Arch Virol. 1994.

Abstract

The replication of human cytomegalovirus (HCMV) was investigated in a new human rhabdomyosarcoma cell line (KFR) with morphological and biochemical characteristics of fetal striated muscle precursors (rhabdomyoblasts). KFR cells exhibited the unique property for spontaneous morphological transformation from a poorly-differentiated state into well-differentiated (myotube-like) rhabdomyoblasts. The poorly-differentiated rhabdomyoblasts promoted both complete viral gene expression and the production of infectious virus. In contrast, in well-differentiated rhabdomyoblasts HCMV infection was abortive. The results showed that replication of HCMV in this human rhabdomyosarcoma cell line depended on the state of cellular differentiation.

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