Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov;47(11):1195-201.
doi: 10.7164/antibiotics.47.1195.

Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus

M E Alvarez  1 , D R Houck, C B White, J E Brownell, M A Bobko, C A Rodger, M B Stawicki, H H Sun, A M Gillum, R Cooper
Affiliations
Free article

Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus

M E Alvarez et al. J Antibiot (Tokyo). 1994 Nov.
Free article

Abstract

Two new peptides, a diketopiperazine of N-methyltyrosine (1) and a tetrapeptide containing N-methyltyrosine (2), were isolated from an actinomycete strain Streptomyces griseus. These compounds inhibit the enzyme calpain in the micromolar range and were characterized on the basis of spectroscopic analysis, amino acid analysis and sequencing. The structure of the tetrapeptide N-methyltyrosyl-N-methyltyrosyl-leucyl-alanine (2), was also confirmed by total synthesis.

PubMed Disclaimer

MeSH terms