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Comparative Study
. 1994 Jun;37(6):902-6.
doi: 10.1002/art.1780370619.

Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies

M Kuwana  1 , Y Okano, J Kaburaki, T Tojo, T A Medsger Jr
Affiliations
Comparative Study

Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies

M Kuwana et al. Arthritis Rheum. 1994 Jun.

Abstract

Objective: To determine racial differences in the frequencies of systemic sclerosis (SSc)-related serum antinuclear antibodies (ANA).

Methods: We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc-related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays.

Results: In comparing the 3 racial groups, we found that anti-U1 RNP, anti-RNA polymerase I, II, and III, and anti-U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti-PM-Scl antibody was found exclusively in Caucasians.

Conclusion: The production of SSc-related serum ANA is related to immunogenetic background.

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