The collection of platelets by apheresis procedures

Abstract

Collection of platelets by apheresis has been a major advance in transfusion medicine. It has allowed the supply of a therapeutically beneficial component to grow with medical needs. Donors find fulfillment in more frequent donations than are possible with whole blood and know that their donation fills a special need. New technology allows leukocyte reduction in the collection of the component with or without the use of filtration. Matching for refractory patients is possible. However, platelets collected by apheresis have not been shown to be hemostatically different from platelets separated from whole blood donations, and thus, do not represent an advance in therapeutic efficacy. The use of apheresis platelets does reduce donor exposure, but this has not been shown to be a safety advance, although it seems intuitively obvious that transfusion risk is statistically reduced in some patients requiring only a few platelet transfusions. Support of patients by apheresis platelets may or may not reduce the risk of alloimmunization. Apheresis platelets from some equipment have less white blood cell contamination even in the absence of filtration, which may be an advantage. Apheresis platelets could be a major step in the ultimate customization of blood collection, in which some donors would preferentially donate red blood cells, whereas others would donate platelets or plasma depending on their blood type and ability to donate frequently, and the current medical need of their donation. Perhaps this would be the most significant advance from the medical progress initiated by Cohn almost 50 years ago.