Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Feb;3(2):359-61.
doi: 10.1002/pro.5560030219.

Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D

C P Ponting  1
Affiliations
Comparative Study

Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D

C P Ponting. Protein Sci. 1994 Feb.

Abstract

An N-terminal region of the acid sphingomyelinase sequence (residues 89-165) is shown to be homologous to saposin-type sequences. By analogy with the known functions of saposins, this sphingomyelinase saposin-type domain may possess lipid-binding and/or sphingomyelinase-activator properties. This finding may prove to be important in the understanding of Niemann-Pick disease, which results from sphingomyelinase deficiency.

PubMed Disclaimer

References

    1. EMBO J. 1982;1(7):801-4 - PubMed
    1. J Biochem. 1993 Jul;114(1):15-20 - PubMed
    1. J Biol Chem. 1988 May 15;263(14):6588-91 - PubMed
    1. Science. 1988 Aug 26;241(4869):1098-101 - PubMed
    1. Biochem Biophys Res Commun. 1988 Oct 14;156(1):403-10 - PubMed

Publication types

LinkOut - more resources