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. 1994 Jun 15;29(3):525-8.
doi: 10.1016/0360-3016(94)90449-9.

Additive effects of cepharanthin in CDDP/hyperthermia combination therapy against transplantable human esophageal cancer in nude mice

T Yano  1 , K Nakatani, A Watanabe, H Sawada, Y Yamada, H Nakano, T Ohnishi
Affiliations

Additive effects of cepharanthin in CDDP/hyperthermia combination therapy against transplantable human esophageal cancer in nude mice

T Yano et al. Int J Radiat Oncol Biol Phys. .

Abstract

Purpose: Additive effects of cepharanthin in CDDP/hyperthermia combination therapy were evaluated.

Methods and materials: Nude mice bearing a transplantable human esophageal cancer (ES0-2), classified histologically as a moderately differentiated squamous cell carcinoma, were treated with cepharanthin (20 mg/kg IP) in addition to cis-diamminedichloroplatinum(II) (CDDP; 4 mg/kg IP) and/or hyperthermia at 42 degrees C for 30 min, to determine the additive effects of cepharanthin. Furthermore, effects of cepharanthin on intratumoral concentration of CDDP were evaluated.

Results: Cepharanthin itself did not have an anti-tumor effect. This agent did not enhance the anti-tumor effect of CDDP alone, but enhanced the anti-tumor effects of both 42 degrees C hyperthermia alone, and combination therapy with CDDP and 42 degrees C hyperthermia. The concentration of CDDP in the tumors treated by 42 degrees C hyperthermia was slightly higher than in nonheated tumors. Cepharanthin did not affect the intratumoral concentration of CDDP, irrespective of whether hyperthermia was applied.

Conclusion: Cepharanthin enhanced the effect of CDDP/hyperthermia combination therapy through thermoenhancing effect.

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