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Clinical Trial
. 1994 May-Jun;14(3):299-303.
doi: 10.1097/01241398-199405000-00005.

Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial

L A Koman  1 , J F Mooney 3rd, B P Smith, A Goodman, T Mulvaney
Affiliations
Clinical Trial

Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial

L A Koman et al. J Pediatr Orthop. 1994 May-Jun.

Abstract

In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.

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