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Case Reports
. 1994 Feb;35(1):104-5.

Neonatal meningitis due to non-encapsulated Haemophilus influenzae in a set of twins--a case report

C T Lim  1 , N Parasakthi, S D Puthucheary
Affiliations
  • PMID: 8009266
Case Reports

Neonatal meningitis due to non-encapsulated Haemophilus influenzae in a set of twins--a case report

C T Lim et al. Singapore Med J. 1994 Feb.

Abstract

A set of twins born to a 24-year-old primigravida had evidence of sepsis 24 to 60 hours after birth and were treated empirically with penicillin and gentamicin. A non-encapsulated H. influenzae biotype IV strain was isolated from the blood cultures of both and from the CSF of twin II. The isolates were beta-lactamase positive and hence showed resistance to ampicillin and therapy was changed to chloramphenicol only. Twin II recovered but Twin I developed a brain abscess in the left occipital region which resolved with extended antibiotic treatment. Although ampicillin-resistant H. influenzae have been reported in Malaysia, invasive disease by such strains are rare.

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