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. 1993 Nov:14 Suppl:S41-4.

[Effects of paracetamol on glutathione S-transferase activity in mice]

[Article in Chinese]
H Wang  1 , R X Peng
Affiliations
  • PMID: 8010073

[Effects of paracetamol on glutathione S-transferase activity in mice]

[Article in Chinese]
H Wang et al. Zhongguo Yao Li Xue Bao. 1993 Nov.

Abstract

Paracetamol (acetaminophen) 90-150 mg.kg-1 increased the activity of serum glutathione S-transferase (GST) and yet reduced the activities of liver microsomal and homogenate GST in mice. The GST activity was dose- and time-related to paracetamol. A negative correlation was found between serum GST and liver homogenate GST, as well as between serum GST and liver microsomal GST. A good positive correlation between serum GST and serum alanine aminotransferase (AAT) was also seen. In addition, butylated hydroxyanisole (BHA) and sodium ferulate (SF) remarkably reversed the changes of serum GST and serum AAT activities in paracetamol-treated mice. These results suggested that the conjugation level in liver was decreased in paracetamol-induced hepatotoxicity in mice.

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