Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1978 Jun;8(4):347-58.
doi: 10.1007/BF01968614.

Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs

R Fantozzi, F Moroni, E Masini, P Blandina, P F Mannaioni
Review

Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs

R Fantozzi et al. Agents Actions. 1978 Jun.

Abstract

Experiments have been reported on the possible modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Adrenergic drugs increase the spontaneous histamine release in vivo, and in neoplastic mast cells, in vitro. The mechanism of histamine release appears to be dependent upon the activation of alpha-adrenoceptors. Cholinergic drugs activate the release of histamine in many secretory processes in vivo; in vitro, acetylcholine is one of the most powerful histamine releasers in isolated purified rat mast cells. The release of histamine evoked by acetylcholine in rat mast cells is a calcium-requiring, temperature-dependent exocytosis. The physiological relationship of the sympathetic, parasympathetic and histamine-containing cells are discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Physiol. 1962 Jan;202:114-6 - PubMed
    1. Acta Pathol Microbiol Scand. 1964;60:156-63 - PubMed
    1. Br J Pharmacol. 1973 Nov;49(3):457-65 - PubMed
    1. Physiol Rev. 1968 Jan;48(1):155-96 - PubMed
    1. Acta Physiol Scand. 1948 Jul 20;15(4):389-400 - PubMed