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Review
. 1994 Jan;86(1):231-2.
doi: 10.1111/j.1365-2141.1994.tb03288.x.

Therapy-related acute promyelocytic leukaemia

M Bhavnani  1 , S A Azzawi, J A Yin, G S Lucas
Affiliations
Review

Therapy-related acute promyelocytic leukaemia

M Bhavnani et al. Br J Haematol. 1994 Jan.

Abstract

We report three patients with acute promyelocytic leukaemia (APL) occurring after treatment for other malignant disorders. One patient had had razoxane (a drug affecting DNA topoisomerase II) for cancer of the colon, and the other two had had treatment for cancer of the breast. Two out of the three patients went into complete remission. We review the published literature on therapy-related acute promyelocytic leukaemia (t-APL) and suggest that it is a genuine clinical entity which may be caused by drugs affecting DNA topoisomerase II, and has a prognosis similar to de novo APL.

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