Histophysiology of the pancreatic islets of Rana tigrina, treated with glucagon
- PMID: 801307
Item in Clipboard
Histophysiology of the pancreatic islets of Rana tigrina, treated with glucagon
Z Mikrosk Anat Forsch.
1976.
Abstract
The effect of mammalian crystalline glucagon (0.5 mg and 2.0 mg/kg) on the blood glucose level and pancreatic islets of Rana tigrina was studied at different stages after its treatment. This frog is moderately sensitive to glucagon and exhibits hyperglycemia and regressive changes, primarily in the beta- and secondarily in the alpha-cells of the islet tissue. The effectiveness of the hormone depends upon the dose employed. The restricted damage in only a fraction of the alpha-cells indicates that this fraction is like the glucagon secreting alpha2-cells of mammals and is the source of glucagon in Rana tigrina also.
Similar articles
-
Insulin administration in the frog Rana tigrina: studies on the blood glucose and the histology of the endocrine pancreas.Gegenbaurs Morphol Jahrb. 1978;124(6):893-4. Gegenbaurs Morphol Jahrb. 1978. PMID: 369939
-
Influence of alloxan administration on the blood glucose, islets of langerhans and some other tissues of the frog, Rana tigrina.Anat Anz. 1978;143(3):242-9. Anat Anz. 1978. PMID: 356673
-
Blood glucose and pancreatic islets in frogs afer streptozotocin treatment.Anat Anz. 1981;150(3):335-42. Anat Anz. 1981. PMID: 6458222
-
Islet cell function: alpha and beta cells--partners towards normoglycaemia.Int J Clin Pract Suppl. 2008 Mar;(159):2-7. doi: 10.1111/j.1742-1241.2007.01686.x. Int J Clin Pract Suppl. 2008. PMID: 18269435 Review.
-
Inhibition of glucagon secretion.Adv Pharmacol. 2005;52:151-71. doi: 10.1016/S1054-3589(05)52008-8. Adv Pharmacol. 2005. PMID: 16492545 Review.