Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jul;14(4):689-92.
doi: 10.1038/jcbfm.1994.86.

Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus

T Beck  1 , D Lindholm, E Castrén, A Wree
Affiliations

Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus

T Beck et al. J Cereb Blood Flow Metab. 1994 Jul.

Abstract

The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB-receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.

PubMed Disclaimer

Publication types

LinkOut - more resources