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Clinical Trial
. 1994 Aug;152(2 Pt 1):407-9.
doi: 10.1016/s0022-5347(17)32750-7.

The efficacy of anti-serotoninergic agents in the treatment of erectile dysfunction

U Kurt  1 , H Ozkardeş, U Altuğ, C Germiyanoğlu, M Gürdal, D Erol
Affiliations
Clinical Trial

The efficacy of anti-serotoninergic agents in the treatment of erectile dysfunction

U Kurt et al. J Urol. 1994 Aug.

Abstract

We investigated 3 agents with antiserotoninergic activity (oral trazodone, ketanserin and mianserin) in a double-blind randomized placebo controlled design in terms of the effectiveness in erectile dysfunction. Positive response rates to 30 days of treatment were 65.2% with trazodone, 19.1% with ketanserin, 31.6% with mianserin and 13.6% with placebo. Response to trazodone treatment was significantly better than with placebo (p = 0.0004) and the other 2 agents (p = 0.03 and p = 0.002 for mianserin and ketanserin, respectively). The effectiveness of ketanserin and mianserin seemed to be greater than that of placebo but the differences did not reach statistical significance (p = 0.63 and p = 0.17, respectively).

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