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Review
. 1994 Apr;19(4):172-6.
doi: 10.1016/0968-0004(94)90280-1.

Poly(ADP-ribose) polymerase: a molecular nick-sensor

G de Murcia  1 , J Ménissier de Murcia
Affiliations
Review

Poly(ADP-ribose) polymerase: a molecular nick-sensor

G de Murcia et al. Trends Biochem Sci. 1994 Apr.

Erratum in

  • Trends Biochem Sci 1994 Jun;19(6):250

Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

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