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. 1994 May;60(5):1561-4.
doi: 10.1128/aem.60.5.1561-1564.1994.

Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone

S Pospísil  1 , P Sedmera, V Havlícek, J Tax
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Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone

S Pospísil et al. Appl Environ Microbiol. 1994 May.

Abstract

Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.

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