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Comparative Study
. 1994 May 16;79(2):175-9.
doi: 10.1016/0304-3835(94)90257-7.

Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture

I Adany  1 , E M Yazlovitskaya, J S Haug, P A Voziyan, G Melnykovych
Affiliations
Comparative Study

Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture

I Adany et al. Cancer Lett. .

Abstract

Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid trans-trans farnesol. Assays of cell numbers and of protein concentrations per culture revealed greater sensitivity of neoplastic cells than of the normal cells. Similar differences were obtained from the comparison of incorporation of [methyl-3H]choline into cellular lipids, with neoplastic cells showing greater inhibition than normal cells.

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