Evidence of possible carcinogenesis during conformational changes in bladder mucosa induced by bladder outlet obstruction

Abstract

Fourier transform infrared spectroscopy with attenuated total reflectance technique was applied to determine the mucosa on the surface of the rabbit urinary bladder wall before and after obstruction. Several abnormal spectra related to the hydrogen bonding in nucleic acids of protein, previously found in the colon malignant tissues, appeared in the infrared spectra of the obstructed bladder mucosa, which could not be found in normal bladder mucosa. Urinary bladder outlet obstruction seemed to induce carcinogenesis in the obstructed bladder mucosa by forming several infrared spectral abnormalities.