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. 1994 Jul:75 ( Pt 7):1785-8.
doi: 10.1099/0022-1317-75-7-1785.

The complete sequence of a human astrovirus

M M Willcocks  1 , T D Brown, C R Madeley, M J Carter
Affiliations

The complete sequence of a human astrovirus

M M Willcocks et al. J Gen Virol. 1994 Jul.

Abstract

We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3' ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.

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