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. 1994 Apr;57(4):545-51.
doi: 10.1021/np50106a021.

Tyrosinase inhibitors from Anacardium occidentale fruits

I Kubo  1 , I Kinst-Hori, Y Yokokawa
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Tyrosinase inhibitors from Anacardium occidentale fruits

I Kubo et al. J Nat Prod. 1994 Apr.

Abstract

Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew [Anacardium occidentale] (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid and 5-[8(Z),11(Z),14-pentadecatrienyl]resorcinol, have indicated that both of these phenolic compounds exhibit characteristic competitive inhibition of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase.

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