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Review
. 1994 Apr;6(2):212-8.
doi: 10.1016/0955-0674(94)90138-4.

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

G M Bokoch  1
Affiliations
Review

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

G M Bokoch. Curr Opin Cell Biol. 1994 Apr.

Abstract

Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the GTP/GDP state of Rac. Proteins exist in leukocytes that are able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated upon phagocyte stimulation.

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